UFC 76: Knockout was a mixed martial arts (MMA) pay-per-view event held by the Ultimate Fighting Championship.

The event took place on September 22, 2007, at the Honda Center in Anaheim, California.

The main event was anticipated to be Chuck Liddell versus Wanderlei Silva, a match between the two former champions of the UFC and PRIDE, respectively; however, the main event featured a fight between former Light Heavyweight Champion Chuck Liddell and The Ultimate Fighter 2 alum Keith Jardine, with both fighters returning from knockout losses at UFC 71.

Also appearing on the card was 2005 Pride Middleweight Grand Prix Champion and future UFC Light Heavyweight Champion Maurício Rua, who made his Octagon debut against TUF 1 winner Forrest Griffin.

Welterweight Diego Sanchez returned after his decision loss at UFC 69 to Josh Koscheck when he faced Jon Fitch, a training partner of Koscheck and a former Purdue University wrestler who was in the midst of a thirteen-fight win streak.