[4][5] By way of replacement, Quinton Jackson, former UFC Light Heavyweight champion, was to fight the undefeated current champion Rashad Evans but had to undergo arthroscopic surgery to repair ligament damage in his jaw that he received in a previous training camp.

[8][9] Chris Wilson was unable to complete the necessary medical paperwork in order to compete at the event and was replaced by Mike Pyle.

[10] James Irvin was set to make his Middleweight debut against Drew McFedries, but was not able to fight due to a knee injury.

Early reports suggested Ed Herman would replace Okami,[13] however Chael Sonnen stepped in to take the bout.

[14] Houston Alexander was scheduled to fight Andre Gusmao, but was forced to pull out due to a broken hand.