[4] The pair previously met at UFC on ESPN: dos Anjos vs. Edwards in 2019 which Pennington won by split decision.

[5] They were also briefly expected to headline UFC on ESPN: Vera vs. Sandhagen, but the bout never materialized.

[8] As a result, a women's strawweight bout between Mackenzie Dern and former Invicta FC Strawweight Champion Angela Hill was moved from UFC on ABC: Rozenstruik vs. Almeida one week prior to instead headline this event.

[11] In turn, Viana withdrew from the bout and was replaced by former LFA Women's Strawweight Champion Lupita Godinez at a catchweight of 120 pounds.

[12] A middleweight bout between Abdul Razak Alhassan and Brunno Ferreira was expected to take place at this event.