The bout between Kenny Florian and Evan Dunham was expected for UFC 126, but was moved to this card to serve as the main event.

Melvin Guillard was pulled from a planned preliminary bout with Yves Edwards and faced Dunham in the main event.

[7] A lightweight bout between Cole Miller and Matt Wiman, which was originally scheduled to take place at UFC 125, was moved to this event.

[11] On January 11, 2011, Dana White announced that if Mark Hominick defeated George Roop at this event, he would become the top contender for the UFC Featherweight Championship and would face champion José Aldo at UFC 129.

[12] On January 18, Dana White announced that the UFC would be streaming the McKenzie vs. Edwards and Johnson vs. Guymon fights for free on their official Facebook page.