[2] The event marked the promotion's ninth visit to São Paulo and first since UFC Fight Night: Błachowicz vs. Jacaré in November 2019.

[2] The event was expected to be headlined by a heavyweight bout between Curtis Blaydes and Jailton Almeida.

[3] However, Blaydes withdrew for unknown reasons and was replaced by former UFC Heavyweight Championship challenger Derrick Lewis.

[10] However, Santos pulled out due to undisclosed reasons and was replaced by promotional newcomer Victor Hugo.

[7] A featherweight bout between Lucas Alexander and David Onama was scheduled to take place in the preliminary card.