On February 19, 2011, Dana White alerted followers on Twitter that Tito Ortiz had to pull out of his fight with Antônio Rogério Nogueira, after receiving a severe cut on his forehead, and would be replaced by Phil Davis.

[3] On March 5, Duane Ludwig was forced out of his fight with Amir Sadollah due to injury.

[5] Also on March 5, Dennis Hallman suffered a knee injury in training and was forced out of his bout against TJ Waldburger.

[6] On March 16, Nick Pace was forced out of his bout against Michael McDonald due to suffering an injury.

[7] Also on March 16, a broken foot forced Nam Phan out of his rematch with Leonard Garcia and was replaced by Chan Sung Jung creating a rematch from their Fight of the Night performance at WEC 48: Aldo vs. Faber, which ended in a controversial decision win for Garcia (29–28, 28–29, 29–28).