UFC on ESPN: Luque vs. dos Anjos

[2] Chris Daukaus was expected to make his light heavyweight debut against Khalil Rountree Jr. at UFC 289, but withdrew in early June due to injury.

[5] A bantamweight bout between Gaston Bolaños and Marcus McGhee was scheduled for this event.

[7] Mike Breeden was expected to face Lando Vannata in a lightweight bout at the event.

[9][10] Da'Mon Blackshear was expected to face Brady Hiestand in a bantamweight bout at the event.

[11] However, Hiestand pulled out in early August due to a medical issue and was replaced by Dana White's Contender Series alum Jose Johnson.