UFC on Fox: VanZant vs. Waterson (also known as UFC on Fox 22) was a mixed martial arts event promoted by the Ultimate Fighting Championship and held on December 17, 2016, at Golden 1 Center in Sacramento, California.

[2] After previously contesting four events in Sacramento at Sleep Train Arena, this was the first for the promotion at the newly built venue.

[2] A women's bout between Paige VanZant and former Invicta FC Atomweight Champion Michelle Waterson served as the event headliner.

[3] The event featured the final fight of former WEC Featherweight Champion and UFC Bantamweight Championship title challenger Urijah Faber, as he faced Brad Pickett, until he made a comeback in 2019.

[4] As a result of the cancellation of UFC Fight Night: Lamas vs. Penn, bouts between James Moontasri vs. Alex Morono and Cole Miller vs. Mizuto Hirota were rescheduled for this event.