Production was handled by Cory Mo, Pimp C, Steve Below, Averexx, DJ B-Do, Mannie Fresh and Akon, with Mike Dean and Giorgio Tuinfort serving as co-producers.

It features guest appearances from 8Ball & MJG, Akon, Big Gipp, B-Legit, E-40, Lil' Boosie, Raheem DeVaughn, Ronald Isley, Sleepy Brown, Snoop Dogg, Too $hort and Webbie.

[2] In March 2008, Bun B confirmed the final UGK studio album would be dedicated to the late Pimp C.[3] The first single "Da Game Been Good to Me" was released onto the Internet on January 16, 2009.

[12] Steve Juon of RapReviews wrote: "from the 'Intro' to the 'Outro' there's very little to not like about UGK 4 Life other than the fact it can never be done again, and any music videos released off this album won't feature Pimp doin' his thang".

[9] Thomas Golianopoulos of Spin called it "a fitting capper to this Texas duo's storied career--nothing groundbreaking, just funky, rough-hewn, celebratory tracks".