uMkhuze Game Reserve (also spelt Mkhuze or Mkuze) is a 40,000-hectare (400 km2; 150 sq mi) game reserve in northern Zululand, KwaZulu-Natal, South Africa.

[1] It was proclaimed a protected area on 15 February 1912.

The reserve has a diversity of natural habitats which include acacia savannah, mixed woodland, sand forest, riverine forest, rivers and pans, grassland, cliffs and rocky ridges.