They have also earned regular and post-season championships in three different conferences, as well as a victory in the College Basketball Invitational (CBI) in 2023.

Bill Foster was hired to succeed Harvey Murphy after the 1969–1970 season as the 49ers moved from the NAIA to Division I as an independent.

Foster's lasting legacy on the program was bringing in two of the most notable players on the team which would advance to the 1977 Final Four: Cedric Maxwell and Melvin Watkins.

Rose inherited a team coming off of two 20-win seasons and led them to the NIT championship game in his first year.

In his first and only head coaching job, Pratt could not maintain the success of the program under Rose, compiling a 56–52 record over four seasons with no postseason appearances.

Following Wissel's dismissal, Jeff Mullins was hired as both head basketball coach and athletic director.

Mullins guided the 49ers through multiple conference changes and kicked off the most successful, sustained run in school history.

Mullins inherited a last place Sun Belt team and things didn't improve in his first season with an 8–20 record.

Watkins had two successful seasons as the Charlotte head coach, leading the team into the second round of the NCAA tournament in both years.

Lutz's run of success in Conference USA is arguably the best sustained stretch in Charlotte basketball history.

The 2000–2001 seasons saw the arrival of Rodney White who would become the top scoring freshman in the country and be named ESPN's National Freshmen of the Year.

They then drew a Memphis team in the CUSA tournament who had under-performed all year but caught fire at the end of the season.

Charlotte eventually joined the Atlantic 10 for all sports along with fellow CUSA member Saint Louis.

The coaching search targeted assistants at successful high-level programs, Major was a member of Thad Matta's staff at Ohio State which included a national title game appearance.

Throughout his career Major has a history of helping highly skilled big men develop into great NBA prospects.

He coached two future #1 overall draft picks in Michael Olowokandi and Greg Oden while at Pacific and Ohio State, respectively.

Major's first season was headlined by the dismissal of one senior big man, Shamarri Spears, in the Fall and another, Phil Jones, not qualifying academically for the Spring semester.

The early season schedule was highlighted by a 49–48 victory over #7 ranked Tennessee and a 2OT win at Georgia Tech.

The 2011–2012 season saw less off-the-court drama, although individual players were benched for disciplinary reasons, but there was little improvement in terms of wins and losses.

This was followed by a miraculous first round A10 tournament victory over Richmond in which Pierriá Henry took 11 free throws in the final 4.7 seconds of game time to overcome a 3-point deficit.

In late April forward E. Victor Nickerson also announced he was transferring, leaving Charlotte with only 6 scholarship players on roster.

The 2013–2014 season, in which the 49ers would rejoin Conference USA and claim the Puerto Rico Tip-Off Championship by beating a ranked Michigan team; ended with a late season 6 game losing streak in conference play, and the 49ers finishing with a 17–14 record and a second round exit from the C-USA Tournament.

[13] Price was fired on December 14, 2017 after a 30-42 record in 2 1/2 seasons at Charlotte and was replaced by assistant coach Houston Fancher.

[14] On March 19, 2018, Ron Sanchez was named the 12th head coach in Charlotte 49ers men’s basketball program history.

Sanchez accompanied Tony Bennett to Virginia in 2009 as an assistant and was promoted to associate head coach in 2015.

[15] On June 6, 2023, Sanchez resigned to rejoin Bennett's staff at Virginia as associate head coach.

[20] The 49ers won their first game in American Conference play when they defeated number seventeen ranked Florida Atlantic.

[22] On February 12, 2024, Fearne was received a contract to become the official head coach of the Charlotte basketball program.

On November 12, 2019, Charlotte won back the Hornets Nest, winning 71-58, and snapping a 6 game losing streak.

ESPN commentator Andy Katz provided this explanation on why Charlotte-Cincinnati was one of the juiciest rivalries in the country: "The games are hotly contested usually and the fans in Charlotte don't like Cincinnati.