It was established in 1884[1] and is affiliated with UPMC (University of Pittsburgh Medical Center) Shadyside Hospital.

The school is currently housed at 5900 Baum Blvd in the AAA Motor Square Garden building.

Originally named the Pittsburgh Training School for Nurses, the school was founded in 1884 by three physicians from Pittsburgh Homeopathic Hospital: Dr. James H. McClelland, Dr. Lewis H. Willard and Dr. Charles F. Bingaman.

They developed the idea for the school after a meeting with Florence Nightingale three years prior.

[4] The school also received the Center of Excellence designation for 2009-2012 by the National League for Nursing.