The facility, which opened on November 21, 2009, is part of the University of Pittsburgh Medical Center (UPMC) system as of February 3, 2020.

The hospital was briefly known as WMHS Braddock Campus before the opening of the Western Maryland Regional Medical Center in 2009.

Western Maryland Health System entered into a clinical affiliation agreement with UPMC in February 2018.

[5] The affiliation was touted by WMHS president and CEO Barry Ronan who stated that "since we became clinically affiliated with UPMC in 2018, we have a stronger clinical and operational position, allowing a broad range of nationally recognized care here locally for the people of Allegany County and surrounding counties in Maryland, Pennsylvania and West Virginia.

The project involved the reuse of several large buildings, including one previously used as the corporate headquarters of The Kelly Springfield Tire Company as well as another that was formerly a call center used by M&T Bank.

[9] UPMC Western Maryland also operates four primary care centers for patients 18 years of age and older.