On August 14, 2013, the Airbus A300 flying the route crashed and burst into flames short of the runway on approach to Birmingham–Shuttlesworth International Airport.

[7]: 7–8, 40 [2][14] The National Transportation Safety Board (NTSB) launched an investigation and sent a 26-member go team to the crash site to collect perishable evidence.

[18] The NTSB stated in late August that no mechanical anomalies had yet been uncovered, but that the complete investigation would take several months.

Excerpts from the CVR were presented, in which both the captain and first officer discussed their lack of sufficient sleep prior to the flight.

[20] On September 9, 2014, the NTSB announced that the probable cause of the accident was that the aircrew had made an unstabilized approach into Birmingham–Shuttlesworth International Airport during which they failed to adequately monitor their altitude.

[21] The NTSB also found that contributing factors in the accident were: In 2014, the Independent Pilots Association filed suit against the FAA to end the cargo airplane exemption from the flight crew minimum rest requirements.

[24] In 2016, the lawsuit was dismissed by a Washington, DC, court, which determined the FAA had acted reasonably by excluding cargo airlines from the rest requirement based on a cost vs benefits analysis.

[7]: 7 UPS Airlines Flight 1354 was also covered in the 10th episode of season 21 on Mayday titled "Deadly Delivery".

[27] This article incorporates public domain material from websites or documents of the National Transportation Safety Board.