Established in 1888, the team is a member of the National Collegiate Athletic Association and the Big Ten Conference.

During his tenure, the program slowly began to rise to national prominence, and Crawford helped to create the California Intercollegiate Baseball Association (CIBA) in 1927.

Crawford compiled an overall record of 59-46-3, including a second-place finish during the initial campaign for the CIBA.

In 1930, Sam Barry took over the USC baseball program and immediately built off of the success his predecessor had.

When Jones died suddenly in 1941, Barry was named his successor, and served as head coach for all three major USC sports teams simultaneously.

Barry was elected to the inaugural class of the American Baseball Coaches Association Hall of Fame in 1966.

After finishing the season 40–12–1, USC met Yale for the 1948 NCAA Division I baseball championship at the second College World Series.

Although USC won, they were unable to prevent future President of the United States of America, George Bush, from collecting a double in the final game.

After taking over in 1951, Dedeaux became the sole coach and proceeded to build on the early success to establish the strongest program in collegiate baseball.

Following the 1957 campaign, Dedeaux's team finished the season 36–8 overall and earned the first of his 10 national championships as sole coach.

Dedeaux drastically changed college baseball and left historic marks on the sport that might never be touched.

Dedeaux won a total of 11 national championships, 10 by himself and one with Sam Barry, compiled a record of 1,332–571–11, and completed a stretch of 37 years without a losing season.

While he was at USC, Dedeaux also served as coach of the United States national baseball team at both the 1964 Summer Olympics in Tokyo, Japan, and the 1984 Summer Olympics in Los Angeles, with baseball being a demonstration sport prior to its elevation to full medal status in 1988.

Following his retirement, Dedeaux became the Director of Baseball for USC, and for the rest of his life remained a beloved annual presence at the College World Series in Omaha, Nebraska.

On July 4, 2006, Dedeaux was inducted as a member of the first class of inductees into the College Baseball Hall of Fame.

USC reached out to Mike Gillespie, one of Rod Dedeaux's former players, to replace the recently retired coach.

During his tenure he was named Pac-10 coach of the year four times, while his teams produced 44 All-America selections, 94 draft picks, and 25 Major League players.

Gillespie replaced Dave Serrano, who had just guided the Anteaters to their first CWS appearance but left to take over at Cal State Fullerton, his alma mater, after George Horton left Fullerton to head the new program at Oregon.

[6] In June 2006, Chad Kreuter became only the fifth man to earn the title of head baseball coach at USC since 1924.

Home plate was located in today's E.F. Hutton Park and left field was bounded by Watt Way.