USS Agile (MSO-421) was an Agile-class minesweeper acquired by the U.S. Navy for the dangerous task of removing mines from minefields laid in the water to prevent ships from passing.

The non-magnetic ocean minesweeper completed fitting out at New York and then sailed on 13 July for her home port, Charleston, South Carolina.

Agile began her first Atlantic Ocean crossing on 12 February 1957, transited the Strait of Gibraltar on the 26th and cruised with the U.S. 6th Fleet for three months.

After turnover at Rhodes, Agile began the long voyage home on 25 May; and she re-entered Charleston with her division mates on 16 June.

However, damage to her propeller forced her into repairs at the Newport News Shipbuilding & Dry Dock Co. and precluded her participation in the exercises.

On 26 October the minesweeper stood out of Charleston on her way to Panama City, Florida, where she reported on the 31st for duty with the Mine Defense Laboratory.

She assisted the laboratory in the conduct of special mine defense tests for five weeks completed that service on 5 December 1957, and headed back to Charleston.

The New Year, 1958, began with a two-week availability alongside a tender February saw Agile pass her final acceptance trials and an operational readiness inspection.

She left the shipyard in January 1962 and after refresher training, resumed operations out of Charleston with the Atlantic Fleet Mine Force.

For a little more than a month, the warship performed service in support of experiments and tests conducted by the Naval mine Defense Laboratory.

The minesweeper made port visits participated in an amphibious exercise at Vieques Island, and joined other American ships off Haiti for a show of force during another of that country's frequent periods of internal disorder.

Agile returned to Charleston on 9 November, underwent two weeks of repairs alongside a tender, and then finished out the year with post-deployment stand down followed by holiday leave and upkeep.

On 5 July, the minesweeper departed her home port once again, bound for Little Creek, Virginia, where she provided services to the Operational Test and Evaluation Force.

The warship completed the repair period on 3 January 1964 Local operations and refresher training filled her time until the last week in March.

Her name was struck from the Naval Vessel Register in September 1977, and she was sold to the Union Minerals & Alloys Corp. in February 1980 for scrapping.