Designed and built to carry out a primary mission of making emergency and routine repairs to ships of the fleet during periods of technical availability, Amphion was equipped with a wide variety of repair shops: shipfitter, carpentry, pipe and copper, sheet metal, welding, canvas, watch, optical, foundry—in short, facilities that employed skilled artificers capable of repairing hardware from precision watches to heavy machinery and hulls.

Her modern engineering plant could generate enough electricity for not only herself but ships moored alongside undergoing repairs.

She also deployed to Bermuda on occasion, as well as to bases in Newfoundland and the Caribbean, carrying out port visits to such places as Ciudad Trujillo, the Dominican Republic; San Juan, Puerto Rico; and St. Thomas, Virgin Islands.

In 1952, singer Gene Vincent spent a two-week training period in her, having previously served on USS Chukawan.

During the summers of 1957 and 1958 Amphion deployed to the Mediterranean, servicing ships of the 6th Fleet and visiting ports in France, Greece, Crete, Sicily, and the Balearic Islands.