Breck served with the Atlantic Fleet, attached to Destroyer Squadron 1 and for six months operated in the Caribbean area.

In June 1921 she rejoined the Destroyer Force and participated in scheduled drills and exercises along the Atlantic coast and for a time had special duty in connection with the calibration of coastal Radio Compass Stations.

In June 1922 she joined Squadrons Escorting fleet, and annually took part in squadron and fleet operations in August 1925 her home yard was changed from Boston, Massachusetts, to Norfolk Navy Yard and Breck was attached to Destroyer Division 25.

Upon returning to the United States, she put in at New York Navy Yard and then proceeded to Newport where she embarked Naval Reserves for the training cruise with the Scouting Fleet.

The succeeding years were similar in the established routine of gunnery practice, war games, and maneuvers until the end of September 1929 when Breck arrived with other units of Destroyer Squadron 9 at Philadelphia Navy Yard, ending her active service.