USS Breckinridge (DD–148) was a Wickes-class destroyer in the United States Navy during World War II, later reclassified as AG-112.

She was employed along the east coast principally in the development and tests of sonar devices until placed out of commission in reserve at Philadelphia on 30 June 1922.

Subsequent to May 1941 Breckinridge was based at Key West, Florida, patrolling and conducting underwater experiments and scheduled exercises.

Breckinridge operated under Commander, Caribbean Sea Frontier, on patrol and escort duties until December 1943 when she was assigned to the Atlantic Fleet.

After undergoing overhaul at Boston Navy Yard between 10 February and 31 March she commenced operations at New London, Connecticut, as flagship of Destroyer Division 54.