Caperton sailed from Boston 8 October 1943 for Pearl Harbor, where she arrived 6 November to begin the operations which would stamp her as one of the "fightingest" destroyers of the Pacific theater.

Tireless TF 58 continued the crescendo pace of its attacks, and in April Caperton screened air strikes preparatory to the invasion of Hollandia, saw the force's planes hit Truk once more, and blasted at Satawan and Ponape in shore bombardment.

Moving on to cover the attacks preparatory to the return of United States forces to Guam, Caperton sailed close inshore to provide lifeguard services for carrier strikes, and on 25 June braved the fire of enemy shore batteries to shell and sink a cargo ship in Apra Harbor.

The destroyer replenished at Ulithi, and resumed screening duty for the strikes intended to deny the Japanese the use of their bases on Okinawa and Formosa in the forthcoming Leyte invasion.

When Reno was torpedoed on 4 November 1944, Caperton took her injured and other survivors on board, and after weathering the furious typhoon of 18 December, she steamed for air strikes on Formosa, Luzon, Cam Ranh Bay, Hong Kong, Canton, and Okinawa.

After further hunter-killer operations off Korea, she sailed on 9 October to call at the Philippines, Singapore, Colombo, Suez, Cannes, and Lisbon, thus rounding the world before her return to Newport 21 May 1954.

Returning to Newport in June, the destroyer's next lengthy deployment was her participation from 3 September to 27 November in NATO Exercise Strikeback in the North Atlantic and Mediterranean.