From 15 January to 9 May 1943, Chandeleur supported South Pacific bases and operations by carrying cargo from San Diego to Efate, Espiritu Santo, Samoa, and Nouméa.

She cleared San Diego 3 June with cargo for Pearl Harbor, Midway, and Wallis, and arrived at Espiritu Santo 1 July.

Following overhaul on the west coast, the seaplane tender made a cargo voyage to Pearl Harbor, then cleared Oakland, California, 18 May for Kwajalein and Eniwetok, arriving 21 June.

At both Eniwetok and Saipan, Chandeleur tended Patrol Squadrons 202 and 216 as they flew missions during the invasion and capture of the Palau Islands.

After a west coast overhaul, Chandeleur sailed to the Philippines to embark men for transportation to Seattle, Washington, where she arrived 11 January 1946.