USS Columbine was a side-wheel steamer that patrolled with the South Atlantic Blockading Squadron of the United States Navy in the American Civil War.

The skirmish which followed, officially known as the Battle of Horse Landing, occurred south of St. Augustine and involved the 2nd Florida Cavalry (Confederate).

She ran aground after 45 minutes of fighting, and Acting Ensign Frank Sandborn went ashore and surrendered the ship to Dickison.

One landsman on the Columbine and three Negro seamen jumped off the boat, swam ashore, and marched some five days finally arriving at St. Augustine, Florida.

The destruction of Columbine was one of the few instances in which a Union warship was destroyed by land-based forces during the Civil War in Florida.