USS De Grasse (AP-164/AK-223), originally SS Nathaniel J. Wyeth, was a Crater-class cargo ship active with the United States Navy during World War II.

De Grasse sailed from Port Hueneme, California, 22 November 1943, with construction battalion troops and cargo, arriving at Pearl Harbor 2 December.

Along with training assault troops in the Hawaiians, she carried men and equipment to the Marshalls and Gilberts on two voyages in February and March 1944.

De Grasse returned to Pearl Harbor 27 July and until the end of 1944 transported troops among the Marshalls, the Gilberts, and the Marianas, and trained men in the Hawaiian area for amphibious assaults.

De Grasse sailed from Pearl Harbor 17 January 1945, to carry troops from Eniwetok, Guam, Saipan, and Majuro to Ulithi, staging point for the Okinawa operation.