USS Doyle C. Barnes (DE-353) was a John C. Butler-class destroyer escort acquired by the U.S. Navy during World War II.

He was reported missing in action 24 August 1942, when his squadron, based on USS Enterprise engaged the Japanese in the Battle of the Eastern Solomons.

Doyle C. Barnes served as a school ship for officers destined for escort vessel service at Norfolk, Virginia, from 25 September to 21 October 1944, then sailed for New Guinea, arriving at Hollandia 28 November.

She escorted convoys from Hollandia to San Pedro Bay, Leyte, patrolled in the Philippines, and took part in the assault and occupation of Borneo from 7 June to 20 July 1945.

Following the cessation of hostilities Doyle C. Barnes remained in the Far East, providing services at Okinawa, Manila, Qingdao, and Shanghai.