USS Duffy (DE-27) was an Evarts-class destroyer escort that served in the Pacific during World War II.

He enlisted in the United States Naval Reserve on 25 April 1941 and was appointed an aviation cadet on 13 November 1941.

Ensign Duffy was killed in action during the Naval Battle of Casablanca, French Morocco, 8 November 1942 during the Allied landings in North Africa.

Duffy was mainly involved in escorting supply ships and as part of larger carrier groups, taking credit for downing a twin-engine Japanese "Betty" bomber in December 1944 at Leyte.

Duffy continued to bombard and wage psychological warfare on various bypassed islands, and on 14 June 1945, she took prisoner seven men of the cutoff garrison on Mille Atoll.