USS Eugene E. Elmore (DE-686) was a Rudderow-class destroyer escort in the United States Navy during World War II.

He graduated from the United States Naval Academy in 1922, and served on a number of ships as well as ashore before reporting 25 October 1940 to USS Quincy.

On 22 April 1944 at Norfolk, Virginia, Eugene E. Elmore joined a hunter-killer group formed around the Bogue-class escort carrier, USS Block Island (CVE-21) and sailed for Casablanca to provide cover for Atlantic convoys.

Eugene E. Elmore sank U-549 in position 31°13′N 23°03′W / 31.217°N 23.050°W / 31.217; -23.050 using her hedgehog spigot mortar system and depth charges, all of the boats 57 crew were lost.

Eugene E. Elmore returned to New York City 13 June 1944, and during the next 4½ months made two voyages escorting convoys to the Mediterranean.