On 18 March 1943, Frazier departed Efate bound for Pearl Harbor and a rendezvous with a task force assigned to operate in the Aleutian Islands.

After firing in the preinvasion bombardment, Frazier covered the landings on Attu 11 May 1943, and patrolled off that island and Kiska, Alaska.

Immediately gaining sonar contact, the destroyer began a depth charge attack which brought air bubbles, oil, and debris to the surface.

Late that night and again on the morning of 11 June, Frazier dropped depth charges on two different underwater contacts, but was unable to determine the results of these attacks; it is likely she sank I-9 in one of them.

After patrolling against submarines off Kwajalein, Frazier returned to Pearl Harbor 15 February screening unladen transports.

From 10 May to 27 July, Frazier patrolled the bypassed Japanese-held islands in the Marshalls, which included Wotje, Jaluit, and Mille.

A west coast overhaul and training at Pearl Harbor preceded Frazier's assignment to escort duty out of Ulithi between 15 December 1944 and the close of the year.

Sailing from San Pedro Bay 13 May 1945, Frazier arrived at Morotai 2 days later, and based here for the Borneo operation.

Assigned to the Philippine Sea Frontier for escort duty at the close of the war, she made voyages to Okinawa and Japan until 3 November, when she sailed for Boston, Massachusetts and Charleston, South Carolina.