The second USS Fresno (CL-121) was a United States Navy Juneau-class light cruiser launched on 5 March 1946 by Federal Shipbuilding and Dry Dock Company of Kearny, New Jersey, sponsored by Mrs. Ruth R. Martin; and commissioned on 27 November 1946, with Captain Elliott Bowman Strauss in command.

During her first operational cruise, from 13 January-7 May 1947, Fresno not only concluded her preliminary training in the Caribbean, but also visited Montevideo, Uruguay, during a presidential inauguration and called at Rio de Janeiro.

[3] A second overseas deployment, from 3 March-19 June 1948, found Fresno visiting Amsterdam, Dublin, Bergen, and Copenhagen from her overseas base at Plymouth, England.

Her coastwise operations from Norfolk included cruises to Prince Edward Island and Bermuda prior to her decommissioning at New York Naval Shipyard on 17 May 1949.

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