USS Grouse (AMS-15/YMS-321) was a YMS-1-class minesweeper of the YMS-135 subclass built for the United States Navy during World War II.

USS Grouse (AMS-15/YMS-321) was laid down as YMS-321 on 29 August 1942[1] by Al Larson Boat Building of Terminal Island, California.

After escorting a convoy to Eniwetok, she swept the harbor at Maug Island, Marianas, 15 March 1945, and then bombarded the beach the following day.

The wooden minesweeper patrolled around Iwo Jima in April 1945 and exploded two floating mines before returning to Saipan.

Although in 1954 and 1955, she was attached to the Hydrographic Office for Project Vamp, a special coastal survey along the Virginia and Massachusetts shores.