After a late winter overhaul, she returned to the Pacific theater in February 1944 operating in support of Vice Admiral Marc A. Mitscher's carrier force during the Truk campaign.

Joining a fast carrier strike force under Vice Admiral John S. McCain, Sr., Guadalupe steamed through Luzon Strait into the South China Sea on the night of 9–10 January 1945, concurrent with the first invasion waves on Lingayen Gulf.

A month's availability at Ulithi to repair her damaged bow ended in late February and Guadalupe again steamed for battle, this time operating in support of the Iwo Jima invasion.

In the post-war period Guadalupe remained on duty in the Pacific, supplying fuel oil to American units in Japan, China, Korea, the Philippines, and scores of islands.

When North Korean Communist troops crossed the 38th parallel on 24 June 1950, Guadalupe was undergoing repairs at Long Beach, California, but quickly re-entered service.

Sailing for the Pacific on 29 July, she spent three months shuttling fuel oil between Hawaii, Kwajalein, and Guam before joining the 7th Fleet at Sasebo, Japan, 1 December 1950.

An uneasy peace settled over the war-torn peninsula in August 1953, while Guadalupe was undergoing overhaul in California, but she returned to the Pacific to support American forces on the Formosa Patrol and training operations.

In her Far East operations, Guadalupe has visited every major Pacific port – Hong Kong, Manila, Tokyo, Ceylon, Formosa – while playing her unsung but vital role in keeping the peace.