USS Guide (AM-447/MSO-447) was an Agile-class minesweeper acquired by the U.S. Navy for the task of removing mines that had been placed in the water to prevent the safe passage of ships.

On 2 April 1959 she again deployed for the Far East, expanding duties to include joint mine exercises with the naval forces of Japan, Korea and Nationalist China.

She arrived off the coast of Vietnam 1 June to begin the first of three periods of "Operation Market Time" anti-infiltration patrols to deny movement of war supplies to the Viet Cong.

While on patrol the ship and crew engaged the enemy in a ship-to-shore fire-fight that resulted in the crewmembers being awarded the Combat Action Medal.

Guide joined in combined mine warfare exercises with units of the Philippine Navy before setting course for the Marshalls, Hawaii, and back to Long Beach, arriving 14 December 1965.