USS Guide (AMc-83) was an Accentor-class coastal minesweeper acquired by the U.S. Navy for the dangerous task of removing mines from minefields laid in the water to prevent ships from passing.

Guide trained from the Mine Warfare School at Yorktown, Virginia, until 17 April 1942 when she sailed to alternately sweep the main shipping channels leading out of Key West, Florida, New Orleans, Louisiana, and Mobile, Alabama.

She periodically made brief visits to Pensacola, Florida, for special sweeping duties.

Her homeport changed from Mobile to Naval Station, Burrwood, Louisiana, in July 1944.

She then served the Mine Countermeasures Station at Panama City, Florida, for the remainder of her career.