After shakedown out of New London, Connecticut, in January 1965, Haddo arrived at her home port, Charleston, South Carolina, on 8 February and joined SubRon 4.

As a result of the outstanding teamwork and many long hours of training and operations during fiscal years 1968 and 1969, Haddo was awarded the Battle Efficiency "E" for Excellence.

After transiting the Panama Canal on 13 February 1976, Haddo's homeport shifted to San Diego, California and joined the Pacific Fleet as a member of Submarine Squadron THREE.

During the first three months of 1978, Haddo accomplished an intensive Selected Restricted Availability at Puget Sound Naval Shipyard in Bremerton, Washington.

In August of the same year she deployed to the Indian Ocean, visited HMAS Stirling in Western Australia from 16–22 December 1980, and returned to San Diego in February 1981.

Haddo arrived at Mare Island Naval Shipyard in April 1982 and underwent an extensive modernization and overhaul in January 1984, returning to San Diego.

Ex-Haddo entered the Nuclear Powered Ship and Submarine Recycling Program in Bremerton, Washington, and on 20 June 1992 ceased to exist.