The destroyer arrived at Purvis Bay, Florida Islands on 14 March to take part in the developing offensive on the northern coast of New Guinea.

With three other destroyers she carried out a bombardment of Japanese positions on New Ireland on 29 May, and in June joined escort carrier Hoggatt Bay on antisubmarine patrol.

A damaged propeller kept her from taking part in the four-part Battle of Leyte Gulf, in which the Imperial Japanese Navy suffered defeat on 24–25 October.

After fighting off heavy air attacks en route, Hopewell arrived off the assault area 15 December and provided fire support as troops stormed ashore.

With Mindoro in Allied hands, and air bases for the Luzon invasion under construction, Hopewell prepared for that operation, to be carried out initially at Lingayen Gulf.

Hopewell joined in the amphibious assault on Corregidor 14 February, and while clearing obstructions from Mariveles Bay with gunfire engaged a large battery on "the rock".

The day of the Japanese surrender, Hopewell sailed from Guam with a refueling group supporting famed Task Force 38 which had done so much to bring victory.

Arriving Puget Sound Navy Yard 8 November, she later moved to San Diego, where she decommissioned 15 January 1947 and was placed in the Pacific Reserve Fleet.

Immediately following shakedown training she steamed westward to Korea 18 June, taking up screening duties with Task Force 77 as carrier based aircraft blasted Communist positions.

During this period of stalemate in the land war, the Navy continued to operate against supply lines and strong points, and Hopewell screened the carriers and heavy ships of Task Force 77.

She returned briefly to Korea to screen battleship Missouri during bombardment operations late in January 1953, and sailed for the United States 3 March 1953.

On 11 November during an amphibious training operation, a single engine attack bomber crashed into Hopewell amidships, killing five and starting gasoline fires.

[1] Returning to active operations again 24 March 1956, when she sailed for the Far East, Hopewell resumed her regular pattern of cruises to Japan, Formosa, and Okinawa interspersed with training and readiness exercises off the West Coast of the United States.