Hutchins took part in campaigns in the Aleutian Islands, amphibious landings at Cape Gloucester, the Wakde-Sarmi operation and Iwo Jima.

After completing shakedown cruise in Casco Bay, Maine, Hutchins got underway from Boston 17 March 1943 and escorted two tankers to Galveston, Texas.

Following an escort voyage to New Caledonia and Espiritu Santo, Hutchins arrived at Pearl Harbor on 30 May for the addition of two twin 40mm gun mounts amidships.

She took part in the occupation of Kiska 15 August after the Japanese left the island and in the following months, patrolled and engaged in fleet training maneuvers.

Hutchins departed the northern Pacific on 18 November 1943 for Milne Bay, New Guinea and screened LSTs during the landings at Cape Gloucester.

During a rain squall, she collided with another destroyer in the congested assault area and was forced to steam to Cairns, Australia 16 January 1944 for repairs to her bow.

During late March and April, Hutchins and other destroyers shelled Wewak and Hansa Bay, as a diversion for the planned assault at Hollandia.

The Japanese destroyers cast off their troop barges with Hutchins and the rest of Crutchley's force in pursuit, exchanging fire at long range.

After a drydock period, Hutchins sailed from Humboldt Bay on 12 September to take part in the Morotai landings, a stepping-stone to the Philippines.

[2] After exchanging gunfire with the Japanese heavy ships, McManes brought the squadron out of range so that the bigger guns of the waiting fleet could engage.

Still undergoing repairs at the end of the war Hutchins was towed to Puget Sound 20 September 1945, decommissioned at Bremerton, Washington 30 November 1945, and sold for scrap in January 1948 to Learner & Co., Oakland, California.