USS Indianapolis (LCS-17) is a Freedom-class littoral combat ship of the United States Navy.

[11] The ship will also feature automated sensors to allow "conditions-based maintenance" and reduce crew overwork and fatigue issues that Freedom had on her first deployment.

Construction began on 18 July 2016 and she was launched on 18 April 2018. she is homeported to Naval Station Mayport, Florida and assigned to Littoral Combat Ship Squadron Two.

[5][13] As of March 2020[update], Indianapolis is billeted to act in the mine countermeasures (MCM) role.

[14] On the morning of September 27, 2024, while transiting the Red Sea with Arleigh Burke class destroyers USS Stockdale (DDG-106) and USS Spruance (DDG-111), she was attacked by roughly two dozen missiles and drones launched by Iranian backed Houthi rebels in Yemen.