USS Iroquois (AT-46) was a tugboat acquired by the United States Navy in anticipation of need for the Spanish–American War.

The second ship to be so named by the Navy, Iroquois—a steam tug—was built as Fearless by Union Iron Works, San Francisco, California in 1892; purchased by the Navy from J. D. Spreckles Bros. & Co. on 18 April 1898 during preparations for the expected war with Spain; and commissioned as Iroquois on 6 July 1898.

She returned to Mare Island on 15 February 1910, and for the next 10 years operated between that base and San Diego, California, as a collier and supply ship.

Following this service, she departed New York on 30 June 1919 for Charleston, South Carolina, then left for San Diego, California, arriving on 27 October.

She served 13th Naval District as a harbor craft out of San Diego until 1925.