USS John Francis Burns (DD-299) was a Clemson-class destroyer built for the United States Navy during World War I.

The ships carried a maximum of 371 long tons (377 t) of fuel oil which was intended gave them a range of 2,500 nautical miles (4,600 km; 2,900 mi) at 20 knots (37 km/h; 23 mph).

Following her return in April, John Francis Burnes operated out of California for 2 years with the exception of fleet maneuvers in the Caribbean in early 1924.

One year later she participated in joint Army-Navy maneuvers out of San Francisco, California before joining fleet operations in Hawaii 27 April 1925.

The destroyer then cruised with a large force in the Pacific, visiting Samoa, Australia, and New Zealand before returning to San Diego in September.