From 4 April 1963 to 30 November 1966, the Blue and Gold crews conducted a total of seventeen deterrent patrols from Holy Loch, Scotland.

After the post-overhaul shakedown, she loaded ballistic missiles at Charleston, South Carolina, and in September 1968 began her eighteenth deterrent patrol.

She was awarded her first Meritorious Unit Commendation as a result of an operation conducted in March 1971 that demonstrated the effectiveness and dependability of the fleet ballistic missile system.

On 1 November 1974, John Marshall began her second refueling overhaul at Mare Island Naval Shipyard at Vallejo, California.

John Marshall arrived in Charleston, South Carolina, on 20 July 1981 and began operations as a unit of Submarine Squadron 4.

[4] Post-overhaul sea trials were conducted in September 1985 and John Marshall joined Submarine Squadron 6 in Norfolk, Virginia, in November 1985.

The deployment included several exercises and a demonstration of her unique special warfare capability and visits to Toulon, France; and La Maddalena, Italy.

Aircraft carrier battlegroup exercises, special acoustic trials, and dry deck shelter operations continued through 1988.

On 1 May 1989, after conducting a variety of exercises with aircraft carrier battlegroups and other submarines, John Marshall departed for her third Mediterranean deployment.

It was the first time a submarine had deployed anywhere in the world with two dry deck shelters on board, adding a unique flexibility and endurance to the fleet commander for special warfare operations.

In September 1991, John Marshall served as flagship for the largest submarine special warfare exercise since World War II.

In 2012, BIC issued a series of lighters commemorating the United States Armed Forces, with proceeds benefiting the USO.