The first USS Lansdale (DD-101) was a Wickes-class destroyer in the United States Navy during World War I and later designated, DM-6 in the years following.

She performed dispatch duty in the Adriatic Sea, principally between Venice and the ports of Austria (on the Croatian coast).

She steamed to Newport, Rhode Island from 2 June to 3 June 1921; joined the Mine Force, Atlantic Fleet on 5 July at Gloucester, Massachusetts; and until late October practiced laying mines off the New England and Virginia coasts under the command of Lt. Cmdr.

On 28 December 1936 she was reduced to a hulk for disposal in accordance with the London Treaty for limitation and reduction of naval armaments.

Her name was struck from the Naval Register on 25 January 1937, and she was sold on 16 March 1939 to Union Shipbuilding Company, Baltimore, Maryland.