USS Louisville was a City-class ironclad gunboat constructed for the U.S. Army by James B. Eads during the American Civil War.

Commanded by Rear Admiral Charles Henry Davis, her squadron captured and sank the Confederate Mississippi flotilla.

On 15 June, she attacked the upper batteries at Vicksburg, before shifting efforts to the White River, departing Helena, Arkansas, 5 August.

After escorting transport Meteor, disembarking troops at Bledsoe's and Hamblen's landings 21 October, Louisville returned to Helena to join the gunboat fleet, Mississippi Squadron.

She joined Baron DeKalb, Cincinnati, Lexington, Signal, New Era, Romeo, Rattler, and Glide later in the month on an expedition up the White River in support of Major General William T. Sherman's army.

She joined Pittsburgh, Mound City and Carondolet on that date, silencing the guns of the fort on Grand Gulf and helping to establish the siege which forced Vicksburg's surrender 4 July 1863.

On learning that Parsson's brigade was 10 miles back of Gaines' Landing, providing reinforcements, Louisville departed immediately for that point, and helped break up the Confederate attack.