The first USS Luce (DD-99) was a Wickes-class destroyer in the United States Navy during World War I and the years following.

Luce departed Boston on 19 September 1918 and reported to Commander Cruiser Force, Atlantic Fleet, in New York two days later.

On 29 October she was transferred to Reserve Squadron 1, Atlantic Fleet, and 18 March 1920 was reclassified Light Mine Layer (DM-4).

Luce recommissioned on 19 March 1930 and sailed to Panama on 18 April where she operated with submarines of the Canal Zone Control Force until May.

She returned to the east coast on 4 June and trained with Mine Squadron 1 until steaming to Boston where she decommissioned for the final time on 31 January 1931.