USS Ludlow (DD-112) was a Wickes-class destroyer built for the United States Navy during World War I.

The turbines were designed to produce a total of 27,000 shaft horsepower (20,000 kW) intended to reach a speed of 35 knots (65 km/h; 40 mph).

The ships carried 225 long tons (229 t) of fuel oil which was intended gave them a range of 2,500 nautical miles (4,600 km; 2,900 mi) at 20 knots (37 km/h; 23 mph).

On 17 July 1920 she was reclassified as a light minelayer and redesignated DM-10, A change of home ports followed 19 January 1921 when she arrived at Pearl Harbor for eight years with Mine Squadron 2, Fleet Base Force.

Ludlow joined in gunnery practice, mining operations antisubmarine training, and fleet battle problems in the Hawaiian Islands and off the United States West Coast, and in 1929 trained Naval Reserves.