[1] In March 2011, McCampbell was the first US Navy vessel on station off northeastern Honshu, Japan to assist with relief efforts after the 2011 Tōhoku earthquake and deliver food, supplies, and other material aid directly to survivors.

[2][3] On 13 June 2011, McCampbell intercepted the North Korean-flagged merchant vessel MV Light, en route to Myanmar, on 26 May, south of Shanghai.

During a routine night mission, the embarked helicopter crew of McCampbell discovered five men signaling for help aboard a mostly-sunk fishing vessel.

[5] McCampbell maintains on board an active VBSS team to conduct anti piracy, anti-smuggling, and anti-terrorist operations.

The ship was an active participant in IMDEX, and the VBSS team was a centerpiece in the multilateral training effort held in conjunction with the exposition.

McCampbell and replenishment oiler Walter S. Diehl "conducted a routine Taiwan Strait Transit" that was "in accordance with international law.

McCampbell will replace USS Antietam (CG 54), which will depart Yokosuka, Japan, and move to Pearl Harbor, Hawaii, as part of a scheduled rotation of forces in the Pacific.

[9] On 2 March 2024, USS McCampbell returned to Yokosuka, Japan after a four year long modernization period in the United States rejoining her sister ships as part of Destroyer Squadron Fifteen.