The ship departed Brooklyn, New York, on 6 October 1944 on the first of 2 voyages escorting convoys to Europe and North Africa.

She was primarily occupied in convoy duty until the end of the war, escorting tankers and other auxiliaries to New Guinea, Ulithi, Palau, Guam, Manila, and Okinawa.

Once she displayed the three star flag of Commander Philippine Sea Frontier as Vice Admiral Kauffman was embarked on an inspection tour of the islands.

The next months were occupied in shelling Communist military and logistics facilities, along with patrol action to clear the area of floating mines, junks, and possible submarines.

With other assignments, she aided Republic of Korea Navy torpedo boats in interdiction missions against enemy supply lines.

In late fall, Naifeh was flagship of the Wonsan Element Commander, protecting United States and Korean minesweepers and firing on shore targets.

In addition to blockade duty, the destroyer escort fired on North Korean supply movements in the Wonsan area.

Naifeh left San Diego on 21 November, arriving at Yokosuka on 9 December for patrol duty off the eastern coast of Korea and anti-submarine training.

Leaving Long Beach, the destroyer escort once again deployed to the western Pacific, arriving at Guam on 30 April.

Berthed at Mare Island until 1 January 1966, when she was struck from the Naval Vessel Register, she was towed to San Diego in early 1966 for stripping prior to being used as a target to destruction.