USS Panama (SP-101) was an armed motorboat that served in the United States Navy as a patrol vessel from 1917 to 1920.

Panama was built as a civilian motorboat in 1914 by Luther Finder, at Key West, Florida.

During her period in commercial service, she saw extensive use in laying underwater telegraph cable for Western Union in and around Key West, and may also have been used as a passenger ship.

The U.S. Navy acquired Panama from the Miami and Nassau Passenger Line on 29 April 1917 for use as a patrol boat during World War I.

On 24 August 1918, during a voyage from the Panama Canal Zone to the United States, she sighted two possible German submarines on her port bow.