After a shakedown in the Atlantic, Pike departed Newport, Rhode Island on 10 February 1937, and proceeded via the Panama Canal to Naval Station San Diego.

[17] Departing Pearl Harbor on 31 March 1943, she fired torpedoes at targets off Truk from 12–14 April, and shelled Satawan Island on the 25th.

[11] Getting under way from Pearl Harbor on 22 July 1943 for her eighth war patrol, Pike sank 2,022-ton Japanese cargo ship Shoju Maru near Marcus Island 5 August.

On 6 August, Pike attacked and damaged a 22,500 ton Kasuga-class aircraft carrier under escort by a Fubuki-class destroyer.

[18][19] On 22 August, Pike sighted a Japanese convoy consisting of six cargo vessels with a Chidori-class torpedo boat escort.

Pike was decommissioned on 15 November 1945 at Boston, Massachusetts, she became a Naval Reserve training ship at Baltimore, Maryland, in September 1946.