USS Pontoosuc was a Union Navy vessel in the American Civil War.

Ordered to the South Atlantic Blockading Squadron on 9 June 1864, she soon returned north and on 12 August departed New York in pursuit of the Confederate raider CSS Tallahassee.

Underway immediately, Pontoosuc continued her search to the north among the fishing fleets in the Gulf of Saint Lawrence.

Tallahassee, however, had turned south en route back to Wilmington, North Carolina.

Seven of Pontoosuc's sailors received the Medal of Honor for their actions during this campaign: Cabin Boy John Anglin, Coxswain Asa Betham, Boatswain's Mate Robert M. Blair, Captain of the Forecastle John P. Erickson, Landsman George W. McWilliams, Chief Quartermaster James W. Verney, and Sailmaker's Mate Anthony Williams.