Upon return from the east coast on 22 April 1924, she put in at Bremerton and decommissioned at the Puget Sound Navy Yard on 10 September.

Departing Mare Island on 1 October, she arrived at Pearl Harbor one week later to commence operations in the Hawaiian area.

On 17 October, she departed San Francisco for Alaskan waters where she issued a load of mines to smaller ships to be planted as a defense for the base at Adak.

She departed San Francisco 8 December 1942, and upon arrival at Espiritu Santo, New Hebrides Islands, on 2 January 1943, became primary ammunition ship for various fleet units that were operating in the area.

Departing San Francisco on 11 November 1943 for Brisbane, Australia, she reported to Commander, Service Force, 7th Fleet on 7 December 1943.

Pyro arrived at Sydney, Australia, on 18 July 1944 for six weeks of repairs, returning 9 September to the new base of operations at Hollandia, where units of the fleet assembled for the invasion of Leyte.

She steamed for Leyte Gulf on 19 December, arriving one week later and remaining in the Philippine area replenishing combatants until 4 August 1945.

In July 1951, the ship was reported as "now being scrapped", with its steam whistle donated for emergency use by the port of Wilmington, Los Angeles.