The first USS Radford (DD–120) was a Wickes-class destroyer in the United States Navy during World War I, later reclassified AG-22.

Assigned to the Destroyer Force, Atlantic Fleet, Radford departed Norfolk on 12 October on a shakedown cruise to Melville, Rhode Island.

She returned to Hampton Roads on 21 October to join the escort force for the Newport News section of Troop Convoy 76 bound for New York City and European waters.

Radford subsequently operated on the U.S. east coast into 1919, sailing southward to Cuba on 14 January 1919.

Designated DD-120 in July 1920, Radford decommissioned on 9 June 1922 and remained in reserve at San Diego for almost 15 years.